Ascentx Medical

Restoring quality of life.

Publications & References

  1. Kamler J, Lemperle G, Lemperle SM, Lehman GA: Endoscopic Lower Esophageal Sphincter Bulking for the Treatment of GERD: Safety Evaluation of Injectable Polymethylmethacrylate Microspheres in Miniature Swine. Gastrointestinal Endoscopy 2010;72:337-342
  2. Lemperle G and Lemperle S: Gastroesophageal Reflux Disease (GERD): An Overview of Current Minimal-Invasive Treatment Potentials. Am J Biomed Sci & Res 2019- 2(6): 253-264 AJBSR.MS.ID.000619.DOI:_10.34297/AJBSR.2019.02.000619
  3. Lemperle G, Lappin PB, Stone C, Lemperle SM: Urethral Bulking with Polymethylmethacrylate Microspheres for Stress Urinary Incontinence: Tissue Persistence and Safety Studies in Miniswine. Urology 2011;77:1005.e1-1005.e7
  4. Lemperle G and Lemperle S: Injectable Bulking Agents for the Treatment of Stress Urinary Incontinence. SM Gerontol Geriatr Res. 2017; 1(1): 1005
  5. Lemperle G, Morhenn V, Pestonjamasp V, Gallo R: Migration Studies and Histology of Injectable Microspheres of Different Sizes in Mice. Plast. Reconstr. Surg. 2004; 113:1380-1390
  6. Morhenn V, Lemperle G, Gallo R: Phagocytosis of Different Particulate Dermal Filler Substances by Human Macrophages and Skin Cells. Dermatol. Surg. 2002; 28:484-490
  7. Lemperle G, Morhenn V, Charrier U: Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation. Aesth. Plast. Surg. 2003; 27:354-366
  8. Lemperle G., Romano J, Busso M: Soft Tissue Augmentation with Artecoll: 10-year History, Indications, Techniques, and Complications. Dermatol. Surg. 2003; 29:573-587
  9. Lemperle G, Knapp TR, Sadick NS, Lemperle SM: ArteFill® Permanent Injectable for Soft Tissue Augmentation: I. Mechanism of Action and Injection Technique. Aesth. Plast. Surg. 2010; 34:264-272
  10. Cohen S, Berner C, Busso M et al.: ArteFill: A Long-Lasting Injectable Wrinkle Filler Material- Summary of the U.S. Food and Drug Administration Trials and a Progress Report on 4- to 5- Year Outcomes. Plast. Reconstr. Surg. 2006; 118 (Suppl): 64S-76S
  11. Cohen S, Dover J, Monheit G et al.: Five-Year Safety & Satisfaction Study of PMMA-Collagen in the Correction of Nasolabial Folds. Dermatol Surg 41:12S: 2015 Dec Suppl: 302S-313S
  12. Joseph JH, Eaton LL, Cohen SR: Current Concepts in the Use of Bellafill. Plast Reconstr Surg. 2015 Nov; 136(5 Suppl): 171S-179S
  13. Karnik J, Baumann L, Bruce S et al.: A double-blind, randomized, multi-center, controlled trial of suspended polymethylmethacrylate microspheres for the correction of atrophic facial acne scars. J Am Acad Dermatol 71; 1:77–83 (2014)
  14. Dong Li, Sheng-Kang Luo, Yi-Chao Wang, Gottfried Lemperle: Facial Volume Restoration with Permanent Dermal Filler (Artecoll-4) in Chinese Women. Facial Plast Surg. 33:537-544 (2017)
  15. Lemperle G: Polymethylmethacrylate Microsphere Injections in the Face. Chapter 81; In: Da Costa A (ed.), Minimally Invasive Aesthetic Procedures. A Guide for Dermatologists and Plastic Surgeons. ISBN 978-3-319-78264-5, 1st ed. 2020, XXXI, 817 p. 1000 illus., 988 illus. in color. ©Springer Nature Switzerland AG 2019 (2020)
  16. Ryou M, Thompson CC: Endoscopic Therapy For GERD: Does It Have a Future? Current Gastroenterology Reports 2008; 10:215-221
  17. Feretis C, Benakis P, Dimopoulos C, et al. Plexiglas (polymethylmethacrylate) Implantation: Technique, pre-clinical and clinical experience. Gastrointest Endoscopy Clin N Am 2003;13:167-78
  18. Connor KW, Lehman GA. Endoscopic placement of collagen at the lower esophageal sphincter to inhibit gastroesophageal reflux: a pilot study of 10 medically intractable patients. Gastrointest Endoscopy 1988;34:106-112
  19. Fornari F, Freitag CP, Duarte ME, Kruel CR, Thomé PR, Sanches PR et al. Endoscopic augmentation of the esophagogastric junction with polymethylmethacrylate: durability, safety, and efficacy after 6 months in mini-pigs. Surg Endosc. 2009;23:2430-37
  20. WSJ Personal Health (A Special Report): The Hidden Dangers of Heartburn: How a Common Health Problem is Quietly Becoming an Unsuspected Killer. By Tara Parker-Pope, The Wall Street Journal, Oct 10, 2005
  21. Boos N, Weissbach S, Rohrbach H, et al.: Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 27:2631-44 (2002)
  22. Teraguchi M, Yoshimura N, Hashizume H, et al.: Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: The Wakayama Spine Study. Osteoarthritis and Cartilage 22:104-110 (2014)
  23. Sambrook PN, MacGregor AJ, Spector TD: Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. Arthritis Rheum 42:366-372 (1999)
  24. Kjaer P, Laboeuf-Yde C, Korsholm L et al.: Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women. Spine 30:1173-80 (2005)
  25. Tan C.I. et al.: Collagen and Elastin crosslinks in human intervertebral discs and ligamentum flavum: age, gender and spinal level influences. J Musculoskelet Res 6:73 (2002)
  26. Taylor W: Biologic collagen PMMA injection (ArteFill) repairs mid-annular concentric defects in the ovine model. Proceedings of the NASS 21st Annual Meeting/ The Spine Journal 6:1S-61S (2006)
  27. Hoshide R, Feldman E, Narayan A, et al. (August 08, 2016): A Novel, Minimally-Invasive Approach to Repair Degenerative Disk Disease in an Ovine Model Using Injectable Polymethyl-Methacrylate and Bovine Collagen (PMMA/BC). Cureus 8(8): e729. DOI 10.7759/cureus.729
  28. American Society for Aesthetic Plastic Surgery (2015 Statistics)
  29. Frazer RQ, Byron RT, et al.: PMMA: An Essential Material in Medicine and Dentistry. Journal of Long-Term Effects of Medical Implants, 15(6) 629-639 (2005)
  30. Piacquadio D, Smith S, Anderson R: A Comparison of Commercially Available Polymethylmethacrylate-based Soft Tissue Fillers. Dermatol Surg. 2008 Jun; 34 Suppl 1: S48-52
  31. Jones DH: Semipermanent and Permanent Injectable Fillers: Dermatol Clin. 2009 Oct; 27(4): 433-44
  32. Gottfried Lemperle, Peter Neugebauer, Ruth Kernke, Karl-Heinz Lerche and Stefan Lemperle: Microspheres for Cosmetic and Medical Injections Must be Free of Phagocytosable Microparticles under 20 Microns. Biomed J Sci & Tech Res 1(6)- 2017. BJSTR.MS.ID.000512. DOI:10.26717/BISTR.2017.01.000512